With the support of the relevant scientific research team of Tangshan People's Hospital and the scientific research team of Beijing neurosurgery Research Institute, relevant experimental research has been carried out. Better financial support is needed, and a mature cooperation model has not yet been established. Through the implementation of this project, research on precise treatment of brain metastases will be vigorously promoted, laying the foundation for the development of molecular detection kits. The improvement of the overall treatment level of malignant tumors is also of great significance, thereby generating objective economic and social benefits. At the same time, a capable translational medicine research team capable of solving practical problems will be established and cultivated. Learn advanced foreign technologies, effectively combine radiation therapy, surgical treatment, chemotherapy, targeted therapy, and even determine the optimal treatment mode for patients with brain metastases through the combination and sequential treatment of targeted drugs. Learn advanced foreign technologies, effectively combine radiation therapy, surgical treatment, chemotherapy, targeted therapy, and even determine the optimal treatment mode for patients with brain metastases through the combination and sequential treatment of targeted drugs. Establish a molecular regulatory network for brain metastases, identify key molecular changes, and conduct preliminary research on their mechanisms of action. Molecular classification biomarker spectrum that ultimately forms brain metastases