
Preparation of polymyxin by genetically engineered bacteria
2023-06-06
release unit:石家庄市冀荣药业有限公司
core technology:
project unit:Shijiazhuang Jirong Pharmaceutical Co., Ltd
industry field:Biological medicine
Project description
The company has established a 100 square meter laboratory molecular biology laboratory, a 50 square meter 100000 level microbial purification room, concentration equipment, crystallization tanks, centrifuges, drying machines, crushers, and mixing machines. A complete set of analytical equipment potentiometric titration, moisture analyzer, horse boiling furnace, spectrophotometer, etc. Constructing engineering bacteria involves cloning large fragments of multiple genes and integrating them into new host bacteria, forming stable expression by removing a portion of the host bacterial genome and inserting large blocks of cloned multiple genes. The expected expression engineering strain can stably express. Polymyxin B1 is a versatile antibiotic. In recent years, with the emergence of iatrogenic drug-resistant bacteria, a variety of modern new antibiotic can not achieve antibacterial effect, leading to the death of patients after infection. Polymyxin B1 can kill these infected bacteria.
favorite